K48-Linked Biotinylated Di-Ubiquitin
Product Sizes
K48-Linked Biotinylated Di-Ubiquitin
£517.00
SI-4802-B100
About this Product
- SKU:
- SI-4802-B100
- Additional Names:
- HMG20;polyubiquitin-C
- Application:
- Cell-based/Functional Assay
- Conjugate:
- Biotin
- Extra Details:
- Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and we once considered the hallmark of this post-translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, the K48 linkage remains a critical pathway for cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These diubiquitin chains generated from the enzymatic linkage of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for the lysine at position 48, limiting chain length.
- Gene Details:
- UBC
- Protein Details:
- P0CG48
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Size:
- 100 ug
- Supplier:
- LifeSensors
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
- Manufacturer's Data Sheet:https://lifesensors.com/product/si4802b-k48-linked-biotinylated-di-ubiquitin/