Ubiquitin- Vinylmethyl ester
Product Sizes
50 ug
£524.00
SI-0240-0050-50UG
About this Product
- SKU:
- SI-0240-0050
- Application:
- Cell-based/Functional Assay
- Extra Details:
- Ub-VME is synthesized by the conjugation of 4-amino-but-2-enoic methyl ester to the C-terminus of UbiquitindeltaG76. Binding of ubiquitin by deubiquitylases (DUBs), for instance UCH's and most USPs, positions the reactive vinyl bond next to the sulfhydryl-group of the active site cysteine. Nucleophilic attack by the sulfhydryl on the vinyl bond produces a stable, covalent thioether bond between Ubiquitin and the deubiquitylase. Thus Ub-VME is a potent suicide inhibitor of DUBs.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- LifeSensors
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
