MZ1
Product Sizes
MZ1
£483.00
PC-1001-0001
About this Product
- SKU:
- PC-1001-0001
- Application:
- Cell-based/Functional Assay
- CAS Number:
- 1797406-69-9
- Extra Details:
- MZ1 is a cell penetrant Proteolysis Targeting Chimera (PROTAC) compound based on (+)-JQ1 conjugated to a von Hippel-Lindau (VHL) ligand. It retains high affinity for BRD2, BRD3 and BRD4 bromodomains (Kd = 13-60 nM) but induces preferential degradation of BRD4 over BRD2 and BRD3. (DC50 values for degradation of BRD4 are 8 and 23 nM in H661 and H838 cells, respectively). MZ1 exhibits potent cytotoxicity and anti-proliferative effects in AML cell lines (pEC50 = 7.6 in Mv4-11 cells).
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Size:
- 1 mg
- Supplier:
- LifeSensors
- Type:
- Biomaterials: Ligands
- Manufacturer's Data Sheet:https://lifesensors.com/product/pc1001-mz1/