Brefeldin A
Product Sizes
5 mg
£251.00
AC-2007-0005-5MG
About this Product
- SKU:
- AC-2007-0005
- Application:
- Cell-based/Functional Assay
- CAS Number:
- 20350-15-6
- Extra Details:
- Brefeldin A is a cell permeable fermentation product from Penicillium brefeldianum. It is a lactone antibiotic and ATPase inhibitor for protein transport with an IC50 of 0.2 uM in HCT 116 cells. Brefeldin A has been widely used as specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. It blocks secretion and prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Brefeldin A also inhibits guanine nucleotide-exchange proteins BIG1 and BIG2, activators of ADP-ribosylation factors. It induces apoptosis independently of p53 and activates sphingomyelin metabolism.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- LifeSensors
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
