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Proteins and Peptides

Magainin 2

Product Sizes
1 mg
AM-101-1MG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
AM-101
Additional Names:
H-GIGKFLHSAKKFGKAFVGEIMNS-OH, GIGKFLHSAKKFGKAFVGEIMNS, 108433-95-0, Magainin 2, antimicrobial, African clawed frog Xenopus laevis, hemolytic, haemolytic, permeabilizing the cell membranes, cytotoxic, cancer, herpes simplex virus, AM-101, AM101, Maganin-2, Mag-2|Maganin-2 , Mag-2
CAS Number:
108433-95-0
Extra Details:
Magainins are closely related 23 amino acid amphipathic cationic peptides with broad-spectrum antimicrobial activities, originally extracted from the skin of the African clawed frog Xenopus laevis. Magainins 1 and magainin 2 are closely related hemolytic peptides which inhibit growth of bacteria by permeabilizing the cell membranes without significant toxicity against mammalian cells. The main target of magainin 1 and 2 is thought to be the lipid matrix of the membranes. Both magainin 1 and 2 are also cytotoxic to cancer cells and exhibit inhibitory action toward herpes simplex virus 1 and 2
Immunogen:
Antibacterials,Antivirals
Molecular Weight:
2466.9
Physical State:
Freeze dried solid
Purity:
>95%
References:
<p>Zasloff (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. <strong>84</strong>(15) 5449-5453 doi:10.1073/pnas.84.15.5449 </p><p>Thwaite et al (2009) The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains. J. Med. Microbiol. <strong>58</strong> 923 https://doi.org/10.1099/jmm.0.008128-0 </p><p>Salnikov and Bechinger (2011) Lipid-controlled peptide topology and interactions in bilayers: structural insights into the synergistic enhancement of the antimicrobial activities of PGLa and magainin 2. Biophys J. <strong>100</strong>(6) 1473 doi: 10.1016/j.bpj.2011.01.070</p>
Sequence:
H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH
Shipping Conditions:
Blue Ice
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
Solubility:
Soluble in dilute acid
Formula:
C114H180N30O29S