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Proteins and Peptides

Indolicidin

Product Sizes
1 mg
AM-070-1MG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
AM-070
Additional Names:
140896-21-5, ILPWKWPWWPWRR-NH2, Indolicidin, cathelicidin, antimicrobial, membrane permeabilization, fungi, protozoa, HIV-1 virus, immune system modulator, AM-070, AM070
CAS Number:
140896-21-5
Extra Details:
Indolicidin is a 13 amino acid cationic cathelicidin family anti-microbial peptide (AMP) isolated from the cytoplasmic granules of bovine neutrophils. Indolicidin exhibits membrane permeabilization effects and antimicrobial activity against a wide spectrum of pathogens which include gram-positive and gram-negative bacteria, fungi, protozoa and the HIV-1 virus. Indolicidin is also an immune system modulator and an inhibitor of aminoglycoside antibiotic resistance enzymes.
Immunogen:
Antibacterials,Antivirals,Antifungals
Molecular Weight:
1906.3
Physical State:
Freeze dried solid
Purity:
>95%
References:
<p>Subbalakshmi and Sitaram (1998) Mechanism of antimicrobial action of indolicidin. FEMS Microbiol. Lett. <strong>160</strong>(1) 91 doi:10.1111/j.1574-6968.1998.tb12896.x </p><p>Sitaram et al (2003) Indolicidin, a 13-residue basic antimicrobial peptide rich in tryptophan and proline, interacts with Ca(2+)-calmodulin. Biochem. Biophys. Res. Commun. <strong>309</strong>(4) 879 doi:10.1016/j.bbrc.2003.08.095 </p><p>Tsai et al (2009) Coupling Molecular Dynamics Simulations with Experiments for the Rational Design of Indolicidin-Analogous Antimicrobial Peptides. J. Mol. Biol. <strong>392</strong>(3) 837 https://doi.org/10.1016/j.jmb.2009.06.071.</p>
Sequence:
H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2
Shipping Conditions:
Blue Ice
Storage Conditions:
Store desiccated and frozen in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
Solubility:
Soluble in dilute acid
Formula:
C100H132N26O13