SOR-C13
About this Product
- SKU:
- TP-020
- Additional Names:
- SOR-C13, TP-020, 1187852-48-7, KEFLHPSKVDLPR
- CAS Number:
- 1187852-48-7
- Extra Details:
- SOR-C13 is a carboxy terminal truncated peptide derived from the 54 residue paralytic peptide soricidin, found in the paralytic venom of the short-tailed shrew Blarina brevicauda. SOR-C13 is a high affinity, use dependent antagonist of human transient receptor potential vanilloid 6 (TRPV6) channels with an IC50 of 14 nM. TRPV6 is a non-voltage gated calcium channel implicated in malignancies and poor prognosis in breast cancer. In vivo, SOR-C13 reduces the growth of human ovarian xenografts in NOD/SCID mouse models.
- Immunogen:
- Transient receptor potential (TRP) channels
- Molecular Weight:
- 1565.81
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Bowen et al (2013) In vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidin. PLoS One <strong>8</strong>(3) e58866 <a href="https://pubmed.ncbi.nlm.nih.gov/23554944/" target="_blank">PMID: 23554944</a><br></p><p>Xue et al (2018) Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model. J Cancer<strong> 9</strong>(17) 3196 <a href="https://pubmed.ncbi.nlm.nih.gov/30210643/" target="_blank">PMID: 30210643</a></p>
- Sequence:
- H-Lys-Glu-Phe-Leu-His-Pro-Ser-Lys-Val-Asp-Leu-Pro-Arg-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C72H116N20O19
