Neurokinin B (human, porcine)
About this Product
- SKU:
- TK-010
- Additional Names:
- Neurokinin B (human, porcine), 86933-75-7, DMHDFFVGLM, DMHDFFVGLM-NH2|NKB
- CAS Number:
- 86933-75-7
- Extra Details:
- Neurokinin B (human, porcine) is a tachykinin agonist peptide that shows preference for the NK3 receptor, with an EC50 of 1 nM. Neurokinin B (human, porcine) is an important endogenous neuropeptide and contributes to luteinizing hormone secretion, the estrous cycle, energy balance, dynamics of fetus in placenta, and contraction in uterine muscles of rat. Loss of function mutations in the genes encoding either neurokinin B or its receptor, NK3 result in hypogonadotropic hypogonadism, implicating NKB and NK3 as essential elements of the human reproductive axis.
- Immunogen:
- Tachykinin receptors
- Molecular Weight:
- 1210.43
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Laufer et al (1985) Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc.Natl.Acad.Sci.U.S.A. <strong>82 </strong>7444 <a href="https://pubmed.ncbi.nlm.nih.gov/2414777/" target="_blank">PMID: 2414777</a></p><p>Rance et al (2010) Neurokinin B and the hypothalamic regulation of reproduction. Brain Res. 1364 <strong>116</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992576/" target="_blank" rel="nofollow">PMID: 20800582</a></p><p>Asmat et al (2020) Exogenous Neurokinin B Administration May Have a Strong Effect on Negative Feedback Loop of Hypothalamic Pituitary Thyroid Axis. Int. J. Peptide Res. Ther. 26 1259 <a href="https://link.springer.com/article/10.1007/s10989-019-09925-0" target="_blank" rel="nofollow">https://doi.org/10.1007/s10989-019-09925-0</a><br></p><p><br></p>
- Sequence:
- H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in DMSO
- Formula:
- C55H79N13O14S2
