Cortistatin 14
About this Product
- SKU:
- SS-020
- Additional Names:
- Cortistatin 14, 193829-96-8, CST-14, PCKNFFWKTFSSCK, SS-020|CST-14
- CAS Number:
- 193829-96-8
- Extra Details:
- Cortistatin 14 is an endogenous neuropeptide that has structural and functional similarities to somatostatin 14. Cortistatin 14 shows potency at all five somatostatin receptors (sst1 - sst5) and prevents somatostatin 14 from binding to them (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Cortistatin 14 has neuronal depressant and sleep modulating properties and co-exists with GABA within the cortex and hippocampus. Cortistatin 14 also binds with much lower potency to the ghrelin and MRGPRX2 receptors.
- Immunogen:
- Mas-related G protein-coupled receptors,Somatostatin receptors
- Molecular Weight:
- 1721.03
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. <strong>232</strong> 157</p><p>Jiang et al (2018) The role of Cortistatin-14 in the gastrointestinal motility in mice. Pharmacol. Rep<strong> 70</strong> 355 https://doi.org/10.1016/j.pharep.2017.09.004</p><p>Jiang et al (2018) Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. <strong>9</strong> 767. doi: 10.3389/fphar.2018.00767<br></p>
- Sequence:
- H-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (disulfide bridge between cysteine 2 and cysteine 13)
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 0.70 mg/ml in water
- Formula:
- C81H113N19O19S2
