Rad17 derived peptide
About this Product
- SKU:
- SP-050
- Additional Names:
- Rad17 derived peptide, SP-050, SP050, ASELPASQPQPFSAKKK
- Extra Details:
- Rad17 derived peptide is an ATR (ATM and Rad-3) related kinase substrate. ATR is a serine/threonine-specific protein kinase that along with ATM (ataxia telangiectasia mutated) is involved in sensing DNA damage and activating the DNA damage checkpoint, leading to cell cycle arrest. ATR inhibition sensitises cancer cells to DNA damaging agents, making it an attractive target for cancer therapy. Rad17 derived peptide is an effective substrate in ATR kinase assays and has been used succesfully to identify novel ATR kinase inhibitors.ChEMBL Assay Report Card ID: CHEMBL3705961
- Immunogen:
- Kinases
- Molecular Weight:
- 1814.07
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Kim et al (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. <strong>274</strong>(53) 37538 <a href="https://pubmed.ncbi.nlm.nih.gov/10608806/" target="_blank" rel="nofollow">PMID: 10608806</a></p><p>Charrier et al (2011) Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. <strong>54</strong>(7) 2320 <a href="https://pubmed.ncbi.nlm.nih.gov/21413798/" target="_blank" rel="nofollow">PMID: 21413798</a></p><p>Kawasumi et al (2014) Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. Cancer Res. <strong>74</strong>(24) 7534<a href="https://pubmed.ncbi.nlm.nih.gov/25336189/" target="_blank" rel="nofollow"> PMID: 25336189 </a></p>
- Sequence:
- H-Ala-Ser-Glu-Leu-Pro-Ala-Ser-Gln-Pro-Gln-Pro-Phe-Ser-Ala-Lys-Lys-Lys-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C81H132N22O25
