DAPT
Product Sizes
5 mg
£118.00
SC-010-5MG
About this Product
- SKU:
- SC-010
- Additional Names:
- 208255-80-5, SC-010, SC010, SC 010, DAPT, LY-374973, LY 374973, LY374973, I³-Secretase Inhibitor IX|LY-374973, I³-Secretase inhibitor IX
- CAS Number:
- 208255-80-5
- Extra Details:
- DAPT is a I³-secretase inhibitor, which can reduce AB Beta40 and AB Beta42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total AB Beta and AB Beta42 respectively. DAPT is also active also in brain extract, cerebrospinal fluid and plasma in vivo, with no no effect on APPA Alpha and APPB Beta levels. DAPT blocks notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) and can cause causes embryonic stem cells (ESCs) to commit to neuronal differentiation. DAPT can be used in a small molecule cocktail to derive cortical neurons from human pluripotent stem cells (hPSCs) and maintain hepatocytes in culture. DAPT also promotes the formation of cone photoreceptors in retinal organoids.
- Immunogen:
- Secretases
- Molecular Weight:
- 432.46
- Physical State:
- Solid
- Purity:
- 98% by TLC, NMR conforms
- Sequence:
- N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
