TLQP 21
About this Product
- SKU:
- RT-020
- Additional Names:
- TLQP 21, RT-020, RT020, 869988-94-3, TLQPPASSRRRHFHHALPPAR, TLQP-21, TLQP21
- CAS Number:
- 869988-94-3
- Extra Details:
- TLQP 21 is a peptide named for its four N-terminal amino acids and length, which is derived from the 617 amino acid VGF precursor by proteolytic processing. The target for TLQP 21 is the C3a receptor-1 (C3aR1), a G-protein coupled receptor that is activated by the complement activation product C3a, itself considered a component of innate immunity. TLQP 21 plays a role in the central and peripheral nervous system to regulate feeding, reproductive and circadian behaviours and has a role in neuropathic pain and peripheral adiposity.
- Immunogen:
- Receptor tyrosine kinases
- Molecular Weight:
- 2432.77
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Bartolomucci et al (2006) TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc Natl Acad Sci U S A. 103(39) 14584 <a href="https://pubmed.ncbi.nlm.nih.gov/16983076/" target="_blank" rel="nofollow">PMID: 16983076</a></p><p>Hannedouche (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. J Biol Chem.<strong> 288</strong>(38) 27434 <a href="https://pubmed.ncbi.nlm.nih.gov/23940034/" target="_blank" rel="nofollow">PMID: 23940034</a></p><p>El Gaamouch et al (2020) VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Mol Neurodegeneration <strong>15</strong> 4 <a href="https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-020-0357-x" target="_blank" rel="nofollow">https://doi.org/10.1186/s13024-020-0357-x</a><br></p>
- Sequence:
- H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C107H170N40O26
