KYL
About this Product
- SKU:
- RT-010
- Additional Names:
- EphA4 blocking peptide
- CAS Number:
- 676657-00-4
- Extra Details:
- KYL is an EphA4 receptor tyrosine kinase inhibitor with a Kd of 0.8 μM. KYL inhibits EphA4-EphrinA5 interactions with an IC50 of 6.34 μM. Through EphA4 inhibition, KYL can prevent dendritic spine reduction, the blocking of LTP induction and neuronal apoptosis caused by amyloid-β oligomers (AβOs). EphA4-/- neurons or sh-EphA4-transfected neurons showed reduced synaptotoxicity by AβOs. EphA4/c-Abl activation is a key-signalling event that mediates the synaptic damage induced by AβOs.
- Molecular Weight:
- 1465.75
- Purity:
- >95% by hplc
- References:
- <p>Lamberto et al (2012) Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. <strong>445</strong> 47 <a href="https://pubmed.ncbi.nlm.nih.gov/22489865/" target="_blank" rel="nofollow">PMID: 22489865</a></p><p>Vargas et al (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One <strong>9</strong> e92309 <a href="https://pubmed.ncbi.nlm.nih.gov/24658113/" target="_blank" rel="nofollow">PMID: 24658113</a></p><p>Tamura et al (2020 EphA4 regulates Aβ production via BACE1 expression in neurons. FASEB J. <strong>34</strong>(12):16383 <a href="https://pubmed.ncbi.nlm.nih.gov/33090569/" target="_blank">PMID: 33090569</a><br></p>
- Sequence:
- H-Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Formula:
- C74H108N14O17