SB 431542
Product Sizes
5 mg
£130.00
RK-030-5MG
About this Product
- SKU:
- RK-030
- Additional Names:
- RK-030, RK030, RK 030, 301836-41-9, SB 431542, SB-431542, SB431542|TGF-B Beta RI Kinase Inhibitor VI
- CAS Number:
- 301836-41-9
- Extra Details:
- SB 431542 is a potent and selective inhibitor of the transforming growth factor-B Beta (TGF-B Beta) type I receptor/ALK5, with an IC50 value of 94 nM, and also inhibits the related ALK4 and ALK7. SB 431542 inhibits TGF-B Beta-induced epithelial to mesenchymal transition (EMT) migration, invasion and VEGF secretion in several human cancer cell lines, and suppresses TGF-B Beta-induced proliferation of human osteosarcoma cells. SB 431542 can replace SOX2 in reprogramming of fibroblasts into induced pluripotent stem cells (iPSCs) and can also be used in a protocol to generate brain organoids from human iPSCs.
- Immunogen:
- Receptor serine/threonine kinase receptors
- Molecular Weight:
- 384.4
- Purity:
- 99% by hplc, NMR conforms
- Sequence:
- 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
