I3-2
About this Product
- SKU:
- PT-120
- Additional Names:
- gamma2|I³-2, peptoid, lipopeptoid, antifungal, PT-120, PT120
- Extra Details:
- I³-2 is a trimeric lipopeptoid with antifungal activity against Cryptococcus neoformans and minimal mammalian cell toxicity. I³-2 is an optimized derivation of AEC5 and has improved potency towards C. neoformans and decreased toxicity towards NIH/3T3 mouse fibroblasts, with a selectivity ratio improved from 8 for AEC5 to 21 for I³-2.
- Immunogen:
- Antifungals
- Molecular Weight:
- 537.8
- Physical State:
- Freeze dried solid
- Purity:
- 95.5% by hplc
- References:
- Middleton et al (2018) Improved Potency and Reduced Toxicity of the Antifungal Peptoid AEC5 Through Submonomer Modification. Bioorg. Med. Chem. Lett. 28(22) 3514 <a href="https://pubmed.ncbi.nlm.nih.gov/30297282/" target="_blank">PMID: 30297282</a>
- Sequence:
- Ntri-NLys-Ntma
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- >50 mg per ml in water
- Formula:
- C28H51N5O3S
