Mca-RPKPVE-Nval-WR-K(Dnp)-NH2
About this Product
- SKU:
- PS-040
- Additional Names:
- Mca-RPKPVE-Nval-WRK(Dnp)-NH2 fluorogenic MMP substrate|Mca-RPKPVE-Nval-WRK(Dnp)-NH2, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate, substrate, MMP-3 , stromelysin 1, stromelysin 2, 7-methoxycoumarin, Mca, 2,4-dinitrophenyl (Dnp), PS-040, PS040
- Conjugate:
- MCA
- Extra Details:
- Mca-RPKPVE-Nval-WRK(Dnp)-NH2, also known as Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate, is an excellent substrate for MMP-3 (stromelysin 1) and MMP-10 (stromelysin 2), but not a substrate MMP-1 or MMP-2. Mca-RPKPVE-Nval-WRK(Dnp)-NH2 substrate contains a highly fluorescent 7-methoxycoumarin (Mca) group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl (Dnp) group. The cleavage site is the peptide bond between Glu and Nval (norvaline). Mca-RPKPVE-Nval-WRK(Dnp)-NH2 is also an excellent substrate for trypsin, HGF activator and factor Xa.
- Immunogen:
- Matrix metalloproteases
- Molecular Weight:
- 1675.9
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Gocheva et al (2006) Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. <strong>20</strong>(5) 543 doi:10.1101/gad.1407406 </p><p>Aly et al (2009) Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med. <strong>13</strong>(8B) 2069 doi: 10.1111/j.1582-4934.2008.00470.x. PMID: 18705699 </p><p>Bertran et al (2020) Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors. Bioorg. Chem. <strong>94</strong> 103365. doi:10.1016/j.bioorg.2019.103365</p>
- Sequence:
- Mca-Arg-Pro-Lys-Pro-Val-Glu-Nval-Trp-Arg-Lys(Dnp)-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C78H110N22O20
