Mca-YVADAP-K(Dnp)-OH
About this Product
- SKU:
- PS-030
- Additional Names:
- 189696-01-3, Mca-YVADAP-K(Dnp)-OH, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, fluorescent, FRET substrate, caspase-1, ICE, PS-030, PS030|Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH
- CAS Number:
- 189696-01-3
- Conjugate:
- MCA
- Extra Details:
- Mca-YVADAP-K(Dnp)-OH, or Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, is a highly fluorescent FRET substrate for the determination of caspase-1 (ICE) and caspase-1-like enzyme activities. Cleavage of Mca-YVADAPK(Dnp)-OH at the P1 Asp residue results in a continuous fluorescent assay which can be monitored at an emission wavelength of 392 nm. Caspase-3 (apopain, CPP-32) is only weakly active on this substrate. Mca-YVADAP-K(Dnp)-OH is a specific substrate for renal ACE 2.
- Immunogen:
- Caspases
- Molecular Weight:
- 1145.1
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Kondo et al (1997) Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells. Proc. Natl. Acad. Sci. <strong>94</strong>(22) 11951 DOI: 10.1073/pnas.94.22.11951 </p><p>Bekhouche et al (2010) Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. J. Biol. Chem.<strong> 285</strong>(21) 15950 doi:10.1074/jbc.M109.086447 </p><p>Bijakowski et al (2012) Sizzled Is Unique among Secreted Frizzled-related Proteins for Its Ability to Specifically Inhibit Bone Morphogenetic Protein-1 (BMP-1)/Tolloid-like Proteinases. J. Biol. Chem. <strong>287</strong> 33581 doi: 10.1074/jbc.M112.380816</p>
- Sequence:
- Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C53H64N10O19
