P2pal-18S
Product Sizes
1 mg
£177.00
PR-120-1MG
About this Product
- SKU:
- PR-120
- Additional Names:
- P2pal-18S pepducin|P2pal-18S, PR-120, PR120, PR 120, Palmitoyl-RSSAMDENSEKKRKSAIK-NH2, P2pal18S
- Extra Details:
- P2pal-18S is a cell-penetrating proteinase-activated receptor-2 (PAR2) antagonist, designed from a structural model of the PAR2 dimer. P2pal-18S is highly selective for PAR2 and has no antagonist activity at the closely related PAR1, PAR4, or CXCR1/2 IL-8 receptors in neutrophil chemotaxis assays. In vitro, P2pal-18S completely suppresses trypsin and mast cell tryptase signaling through PAR2 in neutrophils and colon cancer cells, and in vivo, it is highly efficacious in blocking PAR2-dependent inflammatory responses, preventing the development of neuroinflammatory disease in murine models of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
- Immunogen:
- Protease activated receptors
- Molecular Weight:
- 2302.77
- Physical State:
- Freeze dried solid
- Purity:
- >95% BPLC
- Sequence:
- Palmitoyl-Arg-Ser-Ser-Ala-Met-Asp-Glu-Asn-Ser-Glu-Lys-Lys-Arg-Lys-Ser-Ala-Ile-Lys-NH2
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
