P4pal10
About this Product
- SKU:
- PR-100
- Additional Names:
- P4pal10, Pepducin P4Pal10, Pal-SGRRYGHALR-NH2, 1021346-05-3, PR-100, palmitoyl-SGRRYGHALR-amide, P4pal-10|Pepducin P4Pal10, palmitoyl-SGRRYGHALR-amide, P4pal-10
- CAS Number:
- 1021346-05-3
- Extra Details:
- P4pal10 is a pepducin with a peptide sequence identical to part of the third intracellular loop of the protease activated receptor 4 (PAR4) which acts as a PAR4 antagonist. P4pal10 has no agonist activity as measured by platelet aggregation, intracellular Ca2+ release or InsP production, but preincubation of human platelets with P4pal10 completely blocks aggregation in response to PAR4 activators. Infusion of P4Pal10 into mice extends bleeding time and protects against systemic platelet activation, and in rat models of myocardial injury, P4pal10 treatment before ischemia significantly decreases infarct size when given before, during, and after ischemia. P4Pal10 also inhibits signaling downstream of the GA Alphai-coupled FPR2.
- Immunogen:
- Protease activated receptors,Formyl peptide receptors
- Molecular Weight:
- 1409.72
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Covic et al (2002) Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation. Nat Med. <strong>8</strong>(10) 1161 <a href="https://pubmed.ncbi.nlm.nih.gov/12357249/" target="_blank">PMID: 12357249</a></p><p>Strande et al (2008) Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. J Pharmacol Exp Ther. <strong>324</strong>(3) 1045 <a href="https://pubmed.ncbi.nlm.nih.gov/18055876/" target="_blank">PMID: 18055876</a></p><p>Holdfeldt et al (2020) The PAR4-derived pepducin P4Pal10 lacks effect on neutrophil GPCRs that couple to Gαq for signaling but distinctly modulates function of the Gαi-coupled FPR2 and FFAR2. Biochem Pharmacol. <strong>180</strong> 114143 <a href="https://pubmed.ncbi.nlm.nih.gov/32653592/" target="_blank">PMID: 32653592</a><br></p>
- Sequence:
- Pal-Ser-Gly-Arg-Arg-Tyr-Gly-His-Ala-Leu-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C65H112N22O13
