FSLLRY-NH2
Product Sizes
FSLLRY-NH2
£106.00
PR-080
About this Product
- SKU:
- PR-080
- CAS Number:
- 245329-02-6
- Extra Details:
- FSLLRY-NH2 is a selective PAR2 antagonist. PAR2 is associated with inflammation, metabolism, and disease and FSLLRY-NH2 is correspondingly active in a number of related disease models, it can reverse taxol induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice, it blocks ERK activation and collagen production in isolated cardiac fibroblasts and reduces the level of pro-inflammatory genes IL-8, IL-1β, and TNF-α induced by H2O2 in HepG2 cells. FSLLRY-NH2 reduces symptoms in a mouse model of dermatophyte associated itch and is also effective in human asthma models.
- Molecular Weight:
- 796.97
- Purity:
- >95% by hplc
- References:
- <p>Andoh et al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. <strong>343</strong> 91 <a href="https://pubmed.ncbi.nlm.nih.gov/22761302/" target="_blank" rel="nofollow">PMID: 22761302</a></p><p>Lee et al (2017) Inhibitory effect of FSLLRY-NH2 on inflammatory responses induced by hydrogen peroxide in HepG2 cells. Arch Pharm Res. <strong>40</strong>(7):854 <a href="https://pubmed.ncbi.nlm.nih.gov/28643288/" target="_blank" rel="nofollow">PMID: 28643288</a></p><p>Ocasio-Rivera et al (2020) Targeting of protease activator receptor-2 (PAR-2) antagonist FSLLRY-NH2 as an asthma adjuvant therapy. Medicine (Baltimore) <strong>99</strong>(43) e22351 <a href="https://pubmed.ncbi.nlm.nih.gov/33120736/" target="_blank">PMID: 33120736</a><br></p>
- Sequence:
- H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C39H60N10O8