TRAP 6
About this Product
- SKU:
- PR-070
- Additional Names:
- Thrombin receptor activator peptide 6|TRAP-6, TRAP 6, Thrombin receptor activator peptide 6, 141136-83-6, SFLLRN, PR-070, PR070
- CAS Number:
- 141136-83-6
- Extra Details:
- TRAP 6 is a peptide fragment of protease-activated receptor 1 (PAR1, residues 42-47) that acts as a PAR1 agonist. TRAP 6 stimulates human platelet aggregation with an EC50 of 0.8 uM, promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro. TRAP 6 amide is also available
- Immunogen:
- Protease activated receptors
- Molecular Weight:
- 748.88
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. <strong>267</strong> 6081 <a href="https://pubmed.ncbi.nlm.nih.gov/1313429/" target="_blank" rel="nofollow">PMID: 1313429</a></p><p>Kaufmann et al (1999) PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. <strong>42</strong> 131 <a href="https://pubmed.ncbi.nlm.nih.gov/10421070/" target="_blank">PMID: 10421070</a></p><p>Mitrugno et al (2018) Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395. Platelets <strong>4</strong> 383 <a href="https://pubmed.ncbi.nlm.nih.gov/28523947/" target="_blank" rel="nofollow">PMID: 28523947</a><br></p>
- Sequence:
- H-Ser-Phe-Leu-Leu-Arg-Asn-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C34H56N10O9
