SLIGKV-NH2
About this Product
- SKU:
- PR-060
- Additional Names:
- SLIGKV-NH2, 190383-13-2
- CAS Number:
- 190383-13-2
- Extra Details:
- SLIGKV-NH2 is a protease-activated receptor 2 (PAR2) agonist with a Ki of 9.64 uM and an IC50 of 10.4 uM. SLIGKV-NH2 corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2 and like other peptides corresponding to the tethered ligand sequences of the thrombin receptor and PAR-2 receptor is a full agonist and can be used to investigate receptor function. SLIGKV-NH2 stimulates lactoferrin and IL-8 secretion from human neutrophils.
- Immunogen:
- Protease activated receptors
- Molecular Weight:
- 614.78
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Bohm et al (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J.<strong> 314 </strong>1009 <a href="https://pubmed.ncbi.nlm.nih.gov/8615752/" target="_blank" rel="nofollow">PMID: 8615752</a></p><p>Wang and He (2006) Induction of lactoferrin and IL-8 release from human neutrophils by tryptic enzymes via proteinase activated receptor-2. Cell Biol Int. 30(9) 688 <a href="https://pubmed.ncbi.nlm.nih.gov/16820307/" target="_blank" rel="nofollow">PMID: 16820307</a><br></p><p>Kennedy et al (2018) Structural Characterization of Agonist Binding to Protease-Activated Receptor 2 through Mutagenesis and Computational Modeling. ACS Pharmacol Transl Sci. <strong>1</strong>(2) 119 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088944/" target="_blank" rel="nofollow">PMID: 32219208</a></p>
- Sequence:
- H-Ser-Leu-Ile-Gly-Lys-Val-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C28H54N8O7
