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Proteins and Peptides

tcY-NH2

Product Sizes
1 mg
£165.00
PR-050-1MG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
PR-050
Additional Names:
(trans-Cinnamoyl)-YPGKF-NH2, trans-cinnamoyl-YPGKF-NH2|tcY-NH2, (trans-Cinnamoyl)-YPGKF-NH2, 327177-34-4, trans-Cinnamoyl-YPGKF-NH2
CAS Number:
327177-34-4
Extra Details:
tcY-NH2 is a selective PAR4 antagonist peptide which can block platelet aggregation caused by thrombin, without affecting ADP mediated aggregation. tcY-NH-2 also blocks PAR4 activation of the ERK pathway and through this mechanism can mediate aortic vascular smooth muscle cell migration and proliferation in rat models.
Immunogen:
Protease activated receptors
Molecular Weight:
739.87
Physical State:
Freeze dried solid
Purity:
>95%
References:
<p>Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol.<strong> 79</strong> 439 <a href="https://pubmed.ncbi.nlm.nih.gov/11405248/" target="_blank" rel="nofollow">PMID: 11405248</a></p><p>Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. <strong>143</strong> 443 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575414/" target="_blank" rel="nofollow">PMID: 15451771</a></p><p>Peng (2019) Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function.  Front. Immunology <strong>10</strong> 1311<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591367/" target="_blank" rel="nofollow"> PMID: 31275306</a><a href="https://www.frontiersin.org/articles/10.3389/fimmu.2019.01311/full" target="_blank"></a></p><p><a href="https://pubchem.ncbi.nlm.nih.gov/compound/Tcy-NH2" target="_blank" rel="nofollow">PubChem</a> </p>
Sequence:
trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-N2
Shipping Conditions:
Blue Ice
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
Solubility:
Soluble to 1 mg/ml in water
Formula:
C40H49N7O7