TFLLR-NH2
About this Product
- SKU:
- PR-040
- Additional Names:
- PAR1-AP|TFLLR-NH2, 197794-83-5, TFLLR, PAR1-AP
- CAS Number:
- 197794-83-5
- Extra Details:
- TFLLR-NH2 is a peptide derived from the protease activated receptor 1 (PAR1) that acts as a PAR1 selective agonist, with an EC50 of 1.9 uM. TFLLR-NH2 is widely used to activate platelets and has also been shown to elicit scratching in mice. Platelet activation of SW620 colon cancer cells with TFLLR-NH2 triggers TGF-B Beta secretion, which induces epithelial-mesenchymal transition (EMT) through the downregulation of miR-200b expression. Activated platelets have a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4 on the cell surface.
- Immunogen:
- Protease activated receptors
- Molecular Weight:
- 647.82
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 <a href="https://pubmed.ncbi.nlm.nih.gov/9315351/" target="_blank" rel="nofollow">PMID: 9315351</a></p><p>Mihara et al (2013) Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J Biol Chem.<strong> 288</strong>(46) 32979 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829148/" target="_blank" rel="nofollow">PMID: 24052258</a></p><p>Jia et al (2015) Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Oncology Reports <strong>33</strong>(6) 2681 <a href="https://pubmed.ncbi.nlm.nih.gov/25846512/" target="_blank" rel="nofollow">PMID: 25846512</a><br></p>
- Sequence:
- Thr-Phe-Leu-Leu-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C31H53N9O6
