SLIGRL-NH2
About this Product
- SKU:
- PR-030
- Additional Names:
- PAR-2 activation peptide, SL-NH2|SLIGRL-NH2, 171436-38-7
- CAS Number:
- 171436-38-7
- Extra Details:
- SLIGRL-NH2 is an agonist peptide derived from the N-terminus (aas 39-44) of protease-activated receptor 2 (PAR2). SLIGRL-NH2 activates PAR2 with an EC50 of approximately 5 uM and through its effects on PAR2 it stimulates gastric and intestinal smooth muscle contraction. SLIGRL-NH2 is a pruritogen and causes scratching behaviour in mice.
- Immunogen:
- Protease activated receptors
- Molecular Weight:
- 656.82
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Al-Ani et al (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can.J.Physiol.Pharmacol. <strong>73</strong> 1203 PMID: 8564891</p><p>Chung et al (2019) Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour, Neurobiology of Pain <strong>6</strong> 100032 https://doi.org/10.1016/j.ynpai.2019.100032<br></p><p>Wang et al (2021) Protease-Activated Receptor-2 Decreased Zonula Occlidens-1 and Claudin-1 Expression and Induced Epithelial Barrier Dysfunction in Allergic Rhinitis. American J. Rhinology & Allergy <strong>35</strong>(1) 26 doi:10.1177/1945892420932486</p>
- Sequence:
- H-Ser-Leu-Ile-Gly-Arg-Leu-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C29H56N10O7
