TRAP
About this Product
- SKU:
- PR-010
- Additional Names:
- Thrombin Receptor Agonist Peptide, TRAP, 137339-65-2, SFLLRNPNDKYEPF, TRP42/55, PR-010|TRP42/55, Thrombin receptor agonist peptide
- CAS Number:
- 137339-65-2
- Extra Details:
- TRAP (Thrombin receptor agonist peptide) is a peptide that corresponds to the new N-terminal amino acid sequence of the tethered ligand generated after proteolytic cleavage at arginine-41 of the protease-activated receptor (PAR1) by thrombin. TRAP causes a strong activation response without the complications of fibrinogen cleavage and clot formation when added to platelets.
- Immunogen:
- Protease activated receptors
- Molecular Weight:
- 1739.94
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Vu et al (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell <strong>64</strong> 1057 PMID: 1672265</p><p>Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J.Biol.Chem. <strong>267</strong> 6081 PMID: 1313429</p><p>Nellenbach and Brown (2017), Peptide Mimetic Drugs for Modulating Thrombosis and Hemostasis. Drug Dev. Res. <strong>78</strong> 236 https://doi.org/10.1002/ddr.21407<br></p>
- Sequence:
- H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 0.90 mg/ml in water
- Formula:
- C81H118N20O23
