Peptain-1
Product Sizes
1 mg
£165.00
PP-520-1MG
About this Product
- SKU:
- PP-520
- Additional Names:
- DRFSVNLDVKHFSPEELKVKV, PP-520, PP520, peptain-1, A AlphaB-crystallin (73-93)|A AlphaB-crystallin (73-93)
- Extra Details:
- Peptain-1 is a fragment of the A Alpha-crystallin domain of A AlphaB-crystallin which like the parent protein has the ability to function as a molecular chaperone. A Alpha-Crystallin is a small heat shock protein consisting of A AlphaA- and A AlphaB- subunits; A AlphaB-crystallin is stress-inducible and is present in several tissues including lens, retina, heart, skeletal muscles and kidney, and A AlphaA-crystallin is non inducible and present mainly in lens, where it has a role in lens transparency. In animal models, intraperitoneal injections of peptain-1 block lens epithelial cell apoptosis and cataract formation and reduce stress-induced apoptosis. In glaucoma, axonal degeneration and death of retinal ganglion cells (RGCs) are primary causes of vision loss and in rat models peptain-1 significantly decreases hypoxia-induced RGC loss. Peptain-1 has been used to generate a mouse monoclonal antibody with the aim of blocking the functions of A AlphaB-crystallin. The antibody generated specifically reacts with A AlphaB-crystallin in human and mouse lens proteins, and is also able to inhibit the chaperone and anti-apoptotic activities of peptain-1.
- Immunogen:
- Protein-protein interactions,Epitopes
- Molecular Weight:
- 2485.33
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Asp-Arg-Phe-Ser-Val-Asn-Leu-Asp-Val-Lys-His-Phe-Ser-Pro-Glu-Glu-Leu-Lys-Val-Lys-Val-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
