Tat-3L4F
Product Sizes
1 mg
£189.00
PP-490-1MG
About this Product
- SKU:
- PP-490
- Additional Names:
- Tat-3L4F, PP490, PP-490, YGRKKRRQRRRPNPDQKPRRKKKEKR
- Extra Details:
- Tat-3L4F is a peptide constructed by fusing the 3L4F peptide, a segment of the third intracellular loop of the human 5-HT2C receptor (3L4F refers to third loop, fourth fragment) to the cell-penetrant TAT peptide. The 3L4F fragment, Pro280-Arg295, is a key interface for interaction between the 5-HT2C receptor and the phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome 10), and accordingly Tat-3L4F rapidly and potently disrupts the 5-HT2CR-PTEN interaction in CHO cells. In vitro, Tat-3L4F allosterically augments 5-HT2C mediated signaling in live cells and possesses 5-HT2C receptor agonist like properties, functioning as a positive allosteric modulator. In behavioural tests, Tat-3L4F blocks the conditioned place preference of THC and nicotine, and in olanzapine fed rats it attenuates hyperphagia and weight gain.In some studies Tat-3L4F has been used as the N terminal acetyl and C terminal amide and this variant can be supplied on request.
- Immunogen:
- Protein-protein interactions,Serotonin receptors
- Molecular Weight:
- 3445.06
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Asn-Pro-Asp-Gln-Lys-Pro-Arg-Arg-Lys-Lys-Lys-Glu-Lys-Arg-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
