P140
Product Sizes
1 mg
£189.00
PP-480-1MG
About this Product
- SKU:
- PP-480
- Additional Names:
- Phosphopeptide P140, CEP 33457, Forigerimod, IPP 201101|PP-480. PP480, Lupuzor, P140, IPP-201101, 497156-60-2, CEP 33457; Forigerimod; IPP 201101, Phosphopeptide P140
- CAS Number:
- 497156-60-2
- Extra Details:
- P140 is a peptide from the small nuclear ribonucleoprotein U1-70K, phosphorylated at the Ser140 position. P140 binds to the HSPA8/HSC70 chaperone protein, a constitutively expressed, cognate protein of the HSP70 family, which is involved in many cellular processes and has a key regulatory role in autophagy. Both in vitro and in vivo, P140 interferes with hyperactivated chaperone-mediated autophagy, modifying overexpression of major histocompatibility complex class II molecules and antigen presentation to autoreactive T cells. In a lupus prone murine model, P140 displays tolerogenic and immunomodulatory effects, depleting hyperactivated autoreactive T and B cells and restoring normal immune homeostasis. P140 decreases proteinuria and anti-DNA antibody production, and significantly prolongs survival.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 2638.94
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-Ser-(PO3)-Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
