iSP2
Product Sizes
1 mg
£165.00
PP-470-1MG
About this Product
- SKU:
- PP-470
- Additional Names:
- RRRRRRRRGGWPVIL, STAP-2 derived synthetic peptide, iSP2, PP-470. PP470, R8-SP2-332/336, R8 STAP-2 C332/336|STAP-2-derived synthetic peptide, R8-SP2-332/336, R8 STAP-2 C332/336
- Extra Details:
- iSP2 is a peptide derived from residues of signal-transducing adaptor protein-2 (STAP-2) identified as interacting with cluster of differentiation 3 zeta (CD3zeta) immunoreceptor tyrosine based activation motifs (ITAMs) conjugated to octa-arginine to enhance cell penetrating ability. STAP-2 is an adaptor protein that positively regulates T-cell receptor (TCR) signaling by associating with TCR proximal CD3zeta ITAMs and lymphocyte-specific protein tyrosine kinase. iSP2 directly interacts with the ITAM sequence and competitively inhibits STAP-2 - CD3zeta ITAMs interaction and decreases TCR activation in human and murine T cells. In murine models of experimental autoimmune encephalomyelitis, iSP2 significantly suppresses disease development, to a similar extent to that seen in STAP-2 knockout mice.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 1989.23
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Trp-Pro-Val-Ile-Leu-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
