PDpep1.3
Product Sizes
1 mg
£165.00
PP-430-1MG
About this Product
- SKU:
- PP-430
- Additional Names:
- DEEIERQLKALG, PDpep1.3, PP-430, PP430
- Extra Details:
- PDpep1.3 is a peptide optimised from a hit from a high-throughput screen to identify protein-protein interaction inhibitors that reduce A Alpha-synuclein oligomer levels and their associated cytotoxicity. PDpep1.3 disrupts the direct interaction between the C-terminal region of A Alpha-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B), a component of the endosomal sorting complex required for transport-III (ESCRT-III). A Alpha-Synuclein impedes endolysosomal activity via this interaction with CHMP2B, inhibiting its own degradation, and blockade of it with PDpep1.3 restores endolysosomal function and decreases A Alpha-synuclein levels in human cells. In vivo, PDpep1.3 protects dopaminergic neurons from A Alpha-synuclein-mediated degeneration in Parkinson's disease models in rats.
- Immunogen:
- Protein-protein interactions,Dopamine receptors
- Molecular Weight:
- 1399.73
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Asp-Glu-Glu-Ile-Glu-Arg-Gln-Leu-Lys-Ala-Leu-Gly-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
