IGFBP-3 peptide
Product Sizes
1 mg
£177.00
PP-420-1MG
About this Product
- SKU:
- PP-420
- Additional Names:
- 215-KKGFYKKKQCRPSKGRKR-232|PP-420, PP420, KKGFYKKKQCRPSKGRKR-NH2
- Extra Details:
- IGFBP-3 peptide is a peptide derived from the nuclear localization sequence within the heparin-binding domain of insulin like growth factor binding protein-3 (IGFBP-3), and corresponds to amino acids 215-232 of the full length protein. Both this region and IGFBP-3 peptide bind to glycosaminoglycans including hyaluronan, and also have high affinity and specificity for the mitochondria derived peptide humanin, binding to it with a with a Kd of 120 nM compared with binding of 101 nM for the full-length protein. Both the IGFBP-3 protein and the synthetic IGFBP-3 peptide bind to hyaluronic acid and block its ability to interact with its receptor CD44, and using the synthetic IGFBP-3 peptide to bind hyaluronan inhibits viability of A549 lung cancer cells, an effect correlated with increased apoptosis.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 2221.32
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Lys-Lys-Gly-Phe-Tyr-Lys-Lys-Lys-Gln-Cys-Arg-Pro-Ser-Lys-Gly-Arg-Lys-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
