KGYY15
Product Sizes
1 mg
£165.00
PP-410-1MG
About this Product
- SKU:
- PP-410
- Additional Names:
- KGYY15, PP-410, PP410, KGYY15 peptide, VLQWAKKGYYTMKSN|Mouse KGYY15, KGYY15 peptide
- Extra Details:
- KGYY15 is a peptide derived from amino acids 136 to 150 of the mouse protein CD154, a region determined from crystallography and site-directed mutational analysis to interact with CD40, the type I transmembrane protein found on antigen-presenting cells. CD154 is primarily expressed on activated T cells and CD40 - CD154 interactions are critical in the development and perpetuation of autoimmune disease, making CD40 signaling a target in autoimmunity. In addition to interacting with CD40, KGYY15 interacts with the integrins CD11a/CD18 and CD11b/CD18, and the resulting modulation of CD40-CD154 signalling may be more advantageous than complete inhibition. In vivo, KGYY15 is highly efficient in preventing hyperglycaemia in NOD mice that spontaneously develop type 1 diabetes. KGYY15 can also reverse new-onset hyperglycaemia.
- Immunogen:
- Protein-protein interactions,Integrin receptors
- Molecular Weight:
- 1815.93
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Val-Leu-Gln-Trp-Ala-Lys-Lys-Gly-Tyr-Tyr-Thr-Met-Lys-Ser-Asn-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
