PD-L1Pep-2
Product Sizes
1 mg
£118.00
PP-380-1MG
About this Product
- SKU:
- PP-380
- Additional Names:
- PD-L1-blocking peptide|PD-L1Pep-2, PP-380, PP380, CVRARTR, PD-L1-blocking peptide
- Extra Details:
- PD-L1Pep-2 was identified from a phage-displayed library for peptides that selectively bind to PD-L1-overexpressing cells. PD-L1Pep-2 has a binding affinity of 281 nM, and preferentially binds to high PD-L1-expressing cells over low PD-L1-expressing cells, binding further enhanced by interferon-I³, an inducer of PD-L1 expression. In animal models, intravenously injected PD-L1Pep-2 efficiently targets tumour tissues, inhibits tumour growth, and increases the CD8+/FoxP3+ ratio in mice. PD-L1Pep-2 in combination with doxorubicin inhibits tumour growth more efficiently than doxorubicin alone. PD-L1Pep-2 blockade of PD-L1 reinvigorates T-cell activity and inhibits tumour growth by enhancing anti-tumour immunity.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 860.48
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Cys-Val-Arg-Ala-Arg-Thr-Arg-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
