SMRwt
Product Sizes
1 mg
£189.00
PP-360-1MG
About this Product
- SKU:
- PP-360
- Additional Names:
- Secretion modification region peptide, SMR peptide, Wildtype-3|SMRwt, PP-360, PP360, VGFPVAAVGFPVDYKDDDDK, Secretion modification region peptide, SMR peptide, Wildtype-3
- Extra Details:
- SMRwt is derived from the secretion modification region (SMR, amino acids 66 to 70) of the HIV-1 Nef protein. Nef is a 27-kDa protein produced early during HIV infection of a cell, which interacts with mortalin, a member of the heat shock 70-kDa protein family via Nef's SMR motif, an interaction which is disrupted by the SMRwt peptide. In breast cancer cells SMRwt interacts with mortalin and also the structural protein vimentin to inhibit pro-epithelial-mesenchymal transition (EMT) exosome release, and induce EMT tumour suppressor protein expression. Exosomes containing EMT programs transmit pro-metastatic phenotypes and SMRwt peptide treatment results in an effective blockade of breast cancer cell migration.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 2153.03
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Val-Gly-Phe-Pro-Val-Ala-Ala-Val-Gly-Phe-Pro-Val-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
