RS17
Product Sizes
1 mg
£165.00
PP-330-1MG
About this Product
- SKU:
- PP-330
- Additional Names:
- RS17 RS-17, PP-330, PP330, RRYKQDGGWSHWSPWSS-NH2
- Extra Details:
- RS17 is a peptide which binds to the transmembrane protein CD47 and blocks the interaction of CD47 with the regulatory membrane glycoprotein signal regulatory protein A Alpha (SIRPA Alpha). In normal cells, CD47 interaction with SIRPA Alpha on the macrophage surface membrane sends a phagocytosis inhibiting signal, a mechanism which can be taken advantage of by cancer cells to enable immune escape. RS17 blockade of the CD47 and SIRPA Alpha interaction in cancer cells can prevent phagocytosis evasion, and treatment with RS17 significantly promotes the removal of tumour cells by macrophages. RS17 has a strongly inhibitory effect on tumour growth in a cancer xenograft mouse model.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 2119.28
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Wang et al (2021) An antitumor peptide RS17-targeted CD47, design, synthesis, and antitumor activity. Cancer Med. <strong>10</strong>(6) 2125Â <a href="https://pubmed.ncbi.nlm.nih.gov/33629544/" target="_blank" rel="nofollow">PMID: 33629544</a></p><hr id="null">
- Sequence:
- H-Arg-Arg-Tyr-Lys-Gln-Asp-Gly-Gly-Trp-Ser-His-Trp-Ser-Pro-Trp-Ser-Ser-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C96H131N31O25
