VGN50
Product Sizes
1 mg
£224.00
PP-320-1MG
About this Product
- SKU:
- PP-320
- Additional Names:
- K-Rta Peptide 1, Virus de Gann wo Naosu ORF50, K-Rta peptide|VGN50, VGN 50, PP-320, PP320, K-Rta Peptide 1, Virus de Gann wo Naosu ORF50, rKKRR-Orn-RRR-B BetaAla-LSSILQGLYQLDT
- Extra Details:
- VGN50 is a peptide derived from the Kaposi's sarcoma-associated herpes virus transactivator (K-Rta) sequence, based on the binding interface of K-Rta and cellular coactivators. VGN50 interacts with components of coactivators including nuclear receptor coactivator 2 (NCOA2), p300, and SWItch/Sucrose Non-Fermentable (SWI/SNF), the subfamily of ATP-dependent chromatin remodeling complex proteins. VGN50 blocks recruitment of the SWI/SNF complex and results in downregulation of both MYC and MYC-target gene transcription. Expression of MYC is tightly regulated in normal cells but becomes dysregulated in many types of human cancer cells, and application of VGN50 can reduce cell proliferation and selectively kill cancer cell lines in both tissue culture and a xenograft tumour mouse model.
- Immunogen:
- Nuclear receptor modulators,Protein-protein interactions
- Molecular Weight:
- 2827.7
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Shimoda et al (2021) KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth. Commun Biol. <strong>4</strong>(1) 1330Â <a href="https://pubmed.ncbi.nlm.nih.gov/34857874/" target="_blank" rel="nofollow">PMID: 34857874</a></p><hr id="null">
- Sequence:
- H-(D)Arg-Lys-Lys-Arg-Arg-Orn-Arg-Arg-Arg-B BetaAla-Leu-Ser-Ser-Ile-Leu-Gln-Gly-Leu-Tyr-Gln-Leu-Asp-Thr-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C121H218N46O32
