NP-12
About this Product
- SKU:
- PP-300
- Additional Names:
- AUNP 12, AUR 012, PD-1-derived peptide|NP12, NP-12, 1353563-85-5, AUNP 12, AUR 012, PP-300, PP300, SNTSESF-K(SNTSESF)-FRVTQLAPKAQIKE-NH2
- CAS Number:
- 1353563-85-5
- Extra Details:
- NP-12 is a branched peptide designed from analysis of the strands and loops of programmed cell death protein 1 (PD-1) at the interface of the PD-1/ programmed cell death ligand 1 (PD-L1) interaction. NP-12 binds to PD-L1 and is a functional equipotent antagonist of both PD-L1 and PD-L2 signaling. In preclinical models of melanoma, colon cancer, and kidney cancers, NP-12 showed significant efficacy in inhibiting primary tumour growth and metastasis. NP-12 shows antitumour activity in pre-established tumour models either as a single agent or when in combination with other immunologic cell death agents.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 3261.55
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Sasikumar et al (2019 A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 18(6) 1081 <a href="https://pubmed.ncbi.nlm.nih.gov/31015307/">PMID: 31015307</a>
- Sequence:
- H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(H-Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C142H226N40O48
