TPP-1
About this Product
- SKU:
- PP-280
- Additional Names:
- SGQYASYHCWCWRDPGRSGGSK, TPP-1, PP-280, PP280, 2426685-25-6, targeting PD-L1 peptide, TPP-1 peptide|Targeting PD-L1 peptide, TPP-1 peptide
- CAS Number:
- 2426685-25-6
- Extra Details:
- TPP-1 is a peptide identified through bacterial surface display which binds specifically to programmed cell death ligand 1 (PD-L1), and blocks programmed cell death protein 1 (PD-1)/PD-L1 interaction. TPP-1 binds to free PD-L1 and also cells that express PD-L1 on their cell membranes, and can reverse PD-L1 mediated inhibition of T-cell activation, and inhibit human tumour growth via a T-cell-dependent mechanism. In xenograft mouse models, tumour growth in TPP-1 treated mice was 56% - 71% lower than that in controls.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 2488.67
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Li et al (2018) Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. <strong>6</strong>(2) 178 <a href="https://pubmed.ncbi.nlm.nih.gov/29217732/" target="_blank" rel="nofollow">PMID: 29217732</a>
- Sequence:
- H-Ser-Gly-Gln-Tyr-Ala-Ser-Tyr-His-Cys-Trp-Cys-Trp-Arg-Asp-Pro-Gly-Arg-Ser-Gly-Gly-Ser-Lys-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C107H150N34O32S2
