TAT-ANK
About this Product
- SKU:
- PP-270
- Additional Names:
- ANK peptide|YGRKKRRQRRRQTLQAELLVVYGA, PP-270, TAT-ANK, ANK peptide
- Extra Details:
- TAT-ANK is a peptide derived from amino acid residues 179-191 of the G-protein coupled receptor kinase interacting protein-1 (GIT1) ankyrin domain, which are are crucial for GIT1 binding to the Notch transcription repressor RBP-J. In vitro, application of TAT-ANK significantly inhibits Delta-like 4 (Dll4) expression and Notch 1 activation in human umbilical vein endothelial cells (HUVECs) by competing with activated Notch1 binding to RBP-J, and in mouse models, TAT-ANK reduces tumour size through impairing tumour angiogenesis.
- Immunogen:
- Nuclear receptor modulators,Protein-protein interactions
- Molecular Weight:
- 2946.45
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Zhu et al (2022) A novel peptide inhibitor of Dll4-Notch1 signalling and its pro-angiogenic functions. Br J Pharmacol. 1-16 <a href="https://pubmed.ncbi.nlm.nih.gov/34796471/" target="_blank">PMID: 34796471</a>
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gln-Thr-Leu-Gln-Ala-Glu-Leu-Leu-Val-Val-Tyr-Gly-Ala-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in 50% DMSO and 50% sterile H2O
- Formula:
- C128H221N47O33
