Tat-NTS peptide
About this Product
- SKU:
- PP-260
- Additional Names:
- Tat-NTS|Tat-NTS peptide, PP-260, YGRKKRRQRRRRSFPHLRRVF-NH2
- Extra Details:
- Tat-NTS peptide is a cell-penetrating peptide consisting of Tat fused to amino acid residues R228 to F237 of the repeat III domain of ANXA1, which functions as a unique nuclear translocation signal (NTS). Tat-NTS peptide specifically blocks the interaction of ANXA1 with importin B Beta and consequently the nuclear translocation of ANXA1. Tat-NTS peptide inhibits the transcriptional activity of p53, decreases Bid expression, suppresses activation of the caspase-3 apoptosis pathway and improves survival of neurons subjected to oxygen-glucose deprivation in vitro. In a focal brain ischemia animal model, Tat-NTS peptide reduces neuronal apoptosis in the ischemic zone and effects a dramatic reduction of infarct volume and a parallel improvement in neurological function after reperfusion.
- Immunogen:
- Nuclear receptor modulators,Protein-protein interactions
- Molecular Weight:
- 2855.4
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Li et al (2019) A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1. Cell Death Differ. <strong>26</strong>(2) 260 <a href="https://pubmed.ncbi.nlm.nih.gov/29769639/" target="_blank">PMID: 29769639</a>
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C125H212N54O24
