NFAT Inhibitor
About this Product
- SKU:
- PP-240
- Additional Names:
- NFAT Inhibitor, PP-240, PP240, VIVIT peptide, 249537-73-3, MAGPHPVIVITGPHEE, VIVIT-16|VIVIT peptide, VIVIT-16
- CAS Number:
- 249537-73-3
- Extra Details:
- NFAT inhibitor is a high affinity calcineurin binding peptide which acts as a selective inhibitor of the interaction of calcineurin with the transcription factor nuclear factor of activated T cells (NFAT), which it does without affecting calcineurin phosphatase activity or non-NFAT-mediated signaling. Activation of NFAT by calcineurin is a key step in T cell activation and accordingly NFAT inhibitor peptide blocks NFAT activation and NFAT dependent expression of endogenous T cell cytokine genes. Other cytokines that require calcineurin but not NFAT are not affected. NFAT inhibition by NFAT inhibitor peptide is an effective strategy to quench inflammation and hypertrophy.
- Immunogen:
- Nuclear receptor modulators,Protein-protein interactions
- Molecular Weight:
- 1684.06
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Aramburu et al (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science <strong>285</strong>(5436) 2129 <a href="https://pubmed.ncbi.nlm.nih.gov/10497131/" target="_blank" rel="nofollow">PMID: 10497131</a></p><p>Yu et al (2007) Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders. Cardiovasc Drug Rev.<strong> 25</strong>(2) 175 <a href="https://pubmed.ncbi.nlm.nih.gov/17614939/" target="_blank" rel="nofollow">PMID: 17614939</a></p><p>Ellert-Miklaszewska et al (2021) Delivery of the VIVIT Peptide to Human Glioma Cells to Interfere with Calcineurin-NFAT Signaling. Molecules <strong>26</strong>(16) 4785 <a href="https://pubmed.ncbi.nlm.nih.gov/34443374/" target="_blank" rel="nofollow">PMID: 34443374</a><br></p>
- Sequence:
- H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C75H118N20O22S
