Tat-CIRP
Product Sizes
1 mg
£224.00
PP-230-1MG
About this Product
- SKU:
- PP-230
- Additional Names:
- Tat-cold inducible RNA binding protein|YGRKKRRQRRRGRGFSRGGGDRGYGG, PP-230, PP230, H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly-OH, Tat-cold-inducible RNA binding protein, Trans-trans-activating (Tat)-cold-inducible RNA binding protein
- Extra Details:
- Tat-CIRP is a peptide derived from the high affinity binding region of cold-inducible RNA binding protein (CIRP) which competitively binds to myeloid differentiation factor 2 (MD2) and blocks the MD2-CIRP interaction. MD2 is an essential accessory protein for Toll like receptor 4 (TLR4) activation and blocking the function of MD2 and TLR4 with Tat-CIRP is neuroprotective, reducing apoptosis and necroptosis in vitro. In vivo, Tat-CIRP is neuroprotective against ischemic and hemorrhagic stroke in mice and reduces brain infarct volume and preserves neurological function in rhesus monkeys 30 days after ischemic stroke.
- Immunogen:
- Protein-protein interactions,Toll like receptors
- Molecular Weight:
- 2997.34
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
