F1
About this Product
- SKU:
- PP-220
- Additional Names:
- F1 peptide, TAT-IKIP (46-60)|F1, PP-220, PP220, YGRKKRRQRRRLLSLAMTLGLAWLVF
- Extra Details:
- F1 is a peptide derived from amino acids 46-60 of IkB kinase (IKK) interacting protein (IKIP) fused to a TAT cell penetrating peptide. F1 peptide specifically interacts with IKKalpha/beta to block association with the regulatory subunit NEMO, also known as IKKgamma, thereby inhibiting the phosphorylation of IKKalpha/beta and the activation of NF-kB. F1 reduces LPS induced acute inflammation and attenuates Zymosan-induced acute arthritis in mice.
- Immunogen:
- Nuclear receptor modulators,Protein-protein interactions,Kinases
- Molecular Weight:
- 3189.91
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Liu et al (2021) A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation. J Immunol. Aug 23 ji2100397 Epub ahead of print <a href="https://pubmed.ncbi.nlm.nih.gov/34426543/" target="_blank" rel="nofollow">PMID: 34426543</a>
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Leu-Ser-Leu-Ala-Met-Thr-Leu-Gly-Leu-Ala-Trp-Leu-Val-Phe-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C145H246N48O31S
