p28
Product Sizes
1 mg
£224.00
PP-210-1MG
About this Product
- SKU:
- PP-210
- Additional Names:
- Azurin p28, NSC 745104, p28 (Leu50-Asp77)|p28, PP-210, PP210, PP 210, Azurin p28, NSC 745104, LSTAADMQGVVTDGMASGLDKDYLKPDD
- CAS Number:
- 897026-25-4
- Extra Details:
- p28 is an amphipathic, A Alpha-helical, cell penetrating peptide composed of amino acids Leu50-Asp77 of azurin, a redox protein secreted from the opportunistic pathogen pseudomonas aeruginosa. p28 is a post translational, multitarget anticancer agent that preferentially enters a wide variety of solid tumour cells. On entry, p28 binds to both wild-type and mutant p53 protein, inhibiting constitutional morphogenic protein 1 (cop1) mediated ubiquitination and proteasomal degradation of p53, increasing levels of p53 which induce cell cycle arrest at G2/M and causing apoptosis that results in tumour cell shrinkage and death.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 2914.18
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Leu-Ser-Thr-Ala-Ala-Asp-Met-Gln-Gly-Val-Val-Thr-Asp-Gly-Met-Ala-Ser-Gly-Leu-Asp-Lys-Asp-Tyr-Leu-Lys-Pro-Asp-Asp-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
