T100-Mut
About this Product
- SKU:
- PP-190
- Additional Names:
- T100-Mut, Myr-WKVRQRNKKVQQQESQTALVVNQRCLFA-OH, WKVRQRNKKVQQQESQTALVVNQRCLFA
- Extra Details:
- T100-Mut is a cell permeable peptide which enhances the association of TRPA1 and TRPV1 and strongly inhibits TRPA1 associated pain. The design of T100-Mut originated from Tmem100, a 134-amino acid protein found in dorsal root ganglia (DRG), co-expressed with TRPA1 and TRPV1 with which it forms a complex. Tmem100 decreases the interaction between TRPA1 and TRPV1, whereas a Tmem100 mutant, Tmem100-3Q, exerts the opposite effect and enhances the association of TRPA1 and TRPV1 to inhibit TRPA1. T100-Mut contains the C-terminal sequence of Tmem100-3Q and mimicks the effect of full-length Tmem100-3Q, inhibiting TRPA1-mediated activity and pain in a TRPV1-dependent manner. T100-Mut is also effective in animal models of pain.
- Immunogen:
- Protein-protein interactions,Transient receptor potential (TRP) channels
- Molecular Weight:
- 2451.8
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Weng et al (2014) Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain. Neuron 85(4) 833 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336228/
- Sequence:
- Myr-Trp-Lys-Val-Arg-Gln-Arg-Asn-Lys-Lys-Val-Gln-Gln-Gln-Glu-Ser-Gln-Thr-Ala-Leu-Val-Val-Asn-Gln-Arg-Cys-Leu-Phe-Ala-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C109H186N34O30
