Myr-tat-CBD3
About this Product
- SKU:
- PP-180
- Additional Names:
- Myr-tat-CBD3, N-terminal myristoylated version of TAT-CBD3, axonal collapsin response mediator protein 2, CRMP-2), CaV2.2-CRMP2 interaction, PP-180
- Extra Details:
- Myr-tat-CBD3 is the N-terminal myristoylated version of TAT-CBD3 (PP-140), a peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2). The myristoyl group allows insertion of myr-tat-CBD3 into membranes through hydrophobic interactions and myr-tat-CBD3 is membrane tethered, restricts the CaV2.2-CRMP2 interaction, blocks CaV2.2 trafficking, and strongly inhibits Ca2+ influx from primary sensory neurons. Intrathecal injection of myr-tat-CBD3 reduces carrageenan-induced inflammation and reverses paw incision-induced thermal and mechanical hypersensitivity without producing rewarding behaviour.
- Immunogen:
- Protein-protein interactions,Calcium channels,Transient receptor potential (TRP) channels
- Molecular Weight:
- 3459.2
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Brittain et al (2011) Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex. Nature Med. <strong>17</strong>(7) 822 www.ncbi.nlm.nih.gov/pmc/articles/PMC3219927/ </p><p>Fischer et al (2014) Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion. Gene Ther. <strong>21</strong>(1) 44 doi:10.1038/gt.2013.56 </p><p>François-Moutal eta al (2015) A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain <strong>156</strong>(7) 1247 doi: 10.1097/j.pain.0000000000000147</p>
- Sequence:
- Myr-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Ala-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C148H269N59O33
