TAT-CBD3A6K
About this Product
- SKU:
- PP-150
- Additional Names:
- TAT-CBD3A6K, axonal collapsin response mediator protein 2, CRMP-2), N-type voltage-gated calcium channels, CaV2.2, nociceptive , H-YGRKKRRQRRRARSRLKELRGVPRGL-OH, YGRKKRRQRRRARSRLKELRGVPRGL, PP-150
- Extra Details:
- TAT-CBD3A6K is an optimised variation of CBD3, the 15-amino acid peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2), which is a modulator of N-type voltage-gated calcium channels (CaV2.2), conjugated to the cell penetrating motif of the HIV transduction domain protein TAT. TAT-CBD3A6K binds with greater affinity to Ca2+ channels and is more stable and less prone to unfolding than the parent peptide. TAT-CBD3A6K is anti-nociceptive in a rodent model of AIDS therapy-induced peripheral neuropathy
- Immunogen:
- Protein-protein interactions,Calcium channels
- Molecular Weight:
- 3249.87
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Piekarz et al (2012) CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy. Mol. Pain <strong>8 </strong>54 https://www.ncbi.nlm.nih.gov/pubmed/22828369
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Lys-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C137H250N60O32
