TAT-CBD3
About this Product
- SKU:
- PP-140
- Additional Names:
- TAT-CBD3, H-YGRKKRRQRRRARSRLAELRGVPRGL-OH, YGRKKRRQRRRARSRLAELRGVPRGL, collapsin response mediator protein 2, CRMP-2, N-type voltage-gated calcium channels, CaV2.2, CRMP2 - CaV2.2 interaction, T-type currents, nociceptor, pain, PP-140
- Extra Details:
- TAT-CBD3 is the 15-amino acid peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2) conjugated to the cell penetrating motif of the HIV transduction domain protein TAT, which is a modulator of N-type voltage-gated calcium channels (CaV2.2). TAT-CBD3 functions as a CRMP2 - CaV2.2 interaction inhibitor and reduces CaV2.2 mediated currents, and also reduces T-type currents, which results in reduced nociceptor excitability, diminished neuropeptide release from sensory neurons and lower excitatory synaptic transmission. TAT-CBD3 can also reduce hypersensitive behaviour in chemical-induced inflammatory and neuropathic animal pain models.
- Immunogen:
- Protein-protein interactions,Calcium channels
- Molecular Weight:
- 3192.78
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Brittain et al (2011) Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex. Nature Med. <strong>17</strong>(7) 822 www.ncbi.nlm.nih.gov/pmc/articles/PMC3219927/ </p><p>Fischer et al (2014) Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion. Gene Ther. <strong>21</strong>(1) 44 doi:10.1038/gt.2013.56</p>
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Ala-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C134H243N59O32
