Foxy 5
About this Product
- SKU:
- PP-110
- Additional Names:
- Foxy 5, 881188-51-8, N-Formyl-MDGCEL, PP-110, Foxy5, Foxy-5|Wnt5a hexapeptide, Foxy5
- CAS Number:
- 881188-51-8
- Extra Details:
- Foxy 5 is a formylated hexapeptide derived from the sequence of the Wnt5a ligand which acts as a Wnt5a mimetic. Foxy 5 is able to mimic important effects exerted by the full Wnt5a molecule such as binding to the Frz-5 receptor, and reproducing Wnt5a induced inhibition of human breast cancer cell migration in vitro. Foxy 5 significantly reduces the metastatic spread of WNT5a low DU145 prostate cancer cells in an in vivo orthotopic xenograft mouse model.
- Immunogen:
- Frizzled receptors
- Molecular Weight:
- 694.77
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Säfholm et al (2006) A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J.Biol.Chem. <strong>281</strong> 2740 <a href="https://pubmed.ncbi.nlm.nih.gov/16330545/" target="_blank" rel="nofollow">PMID: 16330545</a></p><p>Säfholm et al (2008) The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin.Cancer Res. <strong>14</strong> 6556 <a href="https://pubmed.ncbi.nlm.nih.gov/18927296/" target="_blank" rel="nofollow">PMID: 18927296</a></p><p>Canesin (2017) Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One <strong>12</strong>(9) e0184418 <a href="https://pubmed.ncbi.nlm.nih.gov/28886116/" target="_blank" rel="nofollow">PMID: 28886116</a><br></p>
- Sequence:
- N-Formyl-Met-Asp-Gly-Cys-Glu-Leu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in PBS
- Formula:
- C26H42N6O12S2
